Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-04-10
1990-12-25
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546144, A61K 3147, G07D21716
Patent
active
049803590
ABSTRACT:
Compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is hydrogen and R.sub.3 is hydrogen or C.sub.1-4 alkyl, or R.sub.2 and R.sub.3 together represent an additional bond as indicated by the dotted line; R.sub.4 is hydrogen, C.sub.1-4 alkyl or phenyl; R.sub.5 is methoxy or ethoxy; R.sub.6 is hydrogen, hydroxy, C.sub.1-4 alkoxy, hydroxy-(C.sub.2-4 alkoxy) or (C.sub.1-4 alkoxy)-(C.sub.2-4 alkoxy); R.sub.7 and R.sub.8 are each independently C.sub.1-4 alkoxy or (C.sub.1-4 alkoxy)-(C.sub.2-4 alkoxy); and R.sub.9 is hydrogen or halogen,
in free form or pharmaceutically acceptable salt form, have pharmaceutical utility, in particular as bronchodilators, eosinophil accumulation and/or activation inhibiting agents and in the treatment of prophylactic treatment of obstructive or inflammatory airways diseases.
REFERENCES:
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patent: 4547508 (1985-10-01), Konz et al.
patent: 4785104 (1988-11-01), Rubloczky et al.
Heterocycles, vol. 9, No. 1, pp. 1-6, (1978).
J. Med. Chem., vol. 22, No. 4, pp. 348-352, (1979).
Hasspacher et al., "Chemical Abstracts", vol. 112, 1990, col. 112:76968y.
Hasspacher Klaus
Naef Reto
Borovian Joseph J.
Hollrah Glennon H.
Honor Robert S.
Sandoz Ltd.
Sharkin Gerald D.
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