Isoquinoline derivatives

Details Isoquinoline derivatives Isoquinoline derivatives

1987-04-21

1989-01-17

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540454, 540485, 540544, 540597, 544128, 546141, C07D40112, C07D21700

Patent

active

047988975

ABSTRACT:
An isoquinoline derivative represented by the formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined in the disclosure, or a pharmacologically acceptable acid salt thereof. These compounds have an excellent relaxation action on blood vessels, particularly coronary arteries, and on bronchial tubes. Accordingly, the compounds can be advantageously utilized as drugs for prevention and treatment of angina, myocardial infarction, cardiovascular thrombosis, cerebrovascular thrombosis, hypertonia, asthma and other various circulatory and respiratory organ diseases.

REFERENCES:
patent: 4456757 (1984-06-01), Hidaka et al.
patent: 4525589 (1985-06-01), Hidaka et al.
patent: 4634770 (1987-01-01), Hidaka et al.
patent: 4678783 (1987-07-01), Hidaka et al.

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