Isoquinoline derivatives

Details Isoquinoline derivatives Isoquinoline derivatives

1991-09-26

1994-11-01

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21716, C07D21724

Patent

active

053609085

ABSTRACT:
A process for the preparation of isoquinoline derivatives of the formulas ##STR1## wherein R.sup.1 and R.sup.2 have the significances herein after set forth in the description, is described.
The compounds of formula IV are obtained by asymmetrically hydrogenating the compounds of formula I. The compounds of formula I are, in turn, obtained by isomerizing compounds of the formulas ##STR2## or a mixture of compounds of the formulas ##STR3##

REFERENCES:
patent: 4727147 (1988-02-01), Wintermeyer et al.
patent: 4851537 (1989-07-01), Noyori et al.
patent: 4857648 (1989-08-01), Broger et al.
patent: 4954644 (1990-09-01), Sayo et al.
Lenz, et al., "J. Org. Chem.", vol. 53, No. 6, 1988, pp. 1176-1183.
Kitamura, et al., "Chemical Abstracts", vol. 111, 1989, Col.111:134625b.
Broger, et al. (II), "Chemical Abstracts," vol. 112, 1990, col. 112.20914k.

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