Isoquinoline compounds

Details Isoquinoline compounds Isoquinoline compounds

2006-07-11

2008-12-30

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S148000, C546S152000

Reexamination Certificate

active

07470787

ABSTRACT:
Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the isoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.

REFERENCES:
patent: 5891646 (1999-04-01), Barak et al.
patent: 6110693 (2000-08-01), Barak et al.
patent: 6787534 (2004-09-01), Haneda et al.
patent: 7329684 (2008-02-01), Mjalli et al.
patent: 7345158 (2008-03-01), Egashira et al.
patent: 7361678 (2008-04-01), Mjalli et al.
patent: 7374891 (2008-05-01), Shahbaz
patent: 7378498 (2008-05-01), Worley et al.
patent: 2004/0091946 (2004-05-01), Oakley et al.
patent: 2005/0032125 (2005-02-01), Oakley et al.
patent: 2005/0282805 (2005-12-01), Hangeland et al.
patent: 2006/0270670 (2006-11-01), Chew et al.
patent: 2007/0111983 (2007-05-01), Fong
patent: 2007/0123561 (2007-05-01), Lee et al.
patent: 2007/0129404 (2007-06-01), Hagihara et al.
patent: 2007/0135499 (2007-06-01), deLong et al.
patent: 2007/0149473 (2007-06-01), Chatterton et al.
patent: 2007/0149548 (2007-06-01), Hellberg et al.
patent: 2007/0173530 (2007-07-01), deLong et al.
patent: 2007/0238741 (2007-10-01), Nagarathnam et al.
patent: 2008/0021026 (2008-01-01), Kahraman et al.
patent: 2008/0021217 (2008-01-01), Borchardt
patent: 2008/0058384 (2008-03-01), Lee et al.
patent: 2008/0096238 (2008-04-01), Sharif et al.
patent: 2008/0125427 (2008-05-01), Sehon et al.
patent: 2008/0139595 (2008-06-01), Schirok et al.
patent: 2008/0153813 (2008-06-01), Chen et al.
patent: 2008/0161297 (2008-07-01), Bosanac et al.
patent: 2008/0167340 (2008-07-01), deLong et al.
patent: 0232569 (1987-08-01), None
patent: 0389995 (1990-10-01), None
patent: 1550660 (2005-07-01), None
patent: 2007236388 (2007-09-01), None
patent: 2007246466 (2007-09-01), None
patent: WO 01/53274 (2001-07-01), None
patent: WO 02/22576 (2002-03-01), None
patent: WO 02/32864 (2002-04-01), None
patent: WO 03/073999 (2003-09-01), None
patent: 03/080578 (2003-10-01), None
patent: WO 2005/020921 (2005-03-01), None
patent: WO 2005/035503 (2005-04-01), None
patent: WO 2005/037257 (2005-04-01), None
patent: WO 2006/041119 (2006-04-01), None
patent: WO 2007/008926 (2007-01-01), None
patent: WO 2007/008942 (2007-01-01), None
patent: 2007/060028 (2007-05-01), None
patent: 2007/076360 (2007-07-01), None
patent: 2007/076367 (2007-07-01), None
patent: 2007/142323 (2007-12-01), None
patent: 2008/011557 (2008-01-01), None
patent: 2008/011560 (2008-01-01), None
patent: 2008/016016 (2008-02-01), None
patent: 2008/036459 (2008-03-01), None
patent: WO 2008/036540 (2008-03-01), None
patent: 2008/049000 (2008-04-01), None
patent: 2008/049919 (2008-05-01), None
patent: 2008/054599 (2008-05-01), None
patent: 2008/077057 (2008-06-01), None
patent: 2008/077550 (2008-07-01), None
patent: 2008/077551 (2008-07-01), None
patent: 2008/077552 (2008-07-01), None
patent: 2008/077553 (2008-07-01), None
patent: 2008/077554 (2008-07-01), None
patent: 2008/077555 (2008-07-01), None
patent: 2008/077556 (2008-07-01), None
patent: 2008/079880 (2008-07-01), None
patent: 2008/079945 (2008-07-01), None
Banker, G.S. et al., Modern Pharmaceutics, Marcel Dekker, Inc., New York, (1979) Chapters 9 and 10.
C.T.F.A. Cosmetic Ingredient Handbook, “Surfactants—Emulsifying Agents”, Second Edition, The Cosmetic, Toiletry, and Fragrance Association, New York, Wenninger, J.A. et al., eds. (1992) 587-592.
Capdeville, R. et al., “Glivec (STI571, IMATINIB), A Rationally Developed, Targeted Anticancer Drug”, Nature Reviews Drug Discovery (2002) 1:493-502.
Dancey, J. et al., “Issues and Progress with Protein Kinase Inhibitors for Cancer Treatment”, Nature Reviews Drug Discovery (2003) 2:296-313.
Hackam, A.S. et al., “The Wnt Signaling Pathway in Retinal Degenerations”, IUBMB Life (2005) 57(6):381-388.
Inouye, Y. et al., “The Absolute Configurations of TRANS-1,2-Cyclopropanedicarboxylic Acid and TRANS-2-Phenylcyclopropanecarboxylic Acid”, Int'l. J. Org. Chem. (1964) 20(5):1695-1699.
Liljebris, C. et al., “Derivatives of 17- Phenyl-18,19,20-trinorprostaglandin F2α Isopropyl Ester: Potential Antiglaucoma Agents,” J. Med. Chem. (1995) 38(2):289-304.
McCutcheon's, “Emulsifiers & Detergents”, North American Edition (1994) vol. 1:236-239.
Oakley, R.H. et al. “The Cellular Distribution of Fluorescently Labeled Arrestins Provides a Robust, Sensitive and Universal Assay for Screening G Protein-Coupled Receptors,” Assay and Drug Development Technologies (2002) 1(1-1):21-30.
Penmetsa, K.V. et al., “Development of Reversed-Phase Chiral HPLC Methods Using Mass Spectrometry Compatible Mobile Phases”, J. Liquid Chroma. Rel. Tech. (2000) 23(6-10):831-839.
Penn, R.B. et al., “Pharmacological Inhibition of Protein Kinases in Intact Cells: Antagonism of Beta Adrenergic Receptor Ligand Binding by H-89 Reveals Limitations of Usefulness.” J. Pharm. Exp. Ther. (1999) 288(2):428-437.
Shankar, G. et al., “Protein-kinase-specific inhibitors block Langerhans' cell migration by inhibiting interleukin-1α release”, Immunology (1999) 96:230-235.
Stirewalt, D.L. et al., “The Role of FLT3 In Haematopoietic Malignancies”, Nature Reviews Cancer (2003) 3:650-665.
Webster, F.X. et al., “Following the Course of Resolution of Carboxylic Acids by 13C NMR Spectrometry of Amine Salts” J. Org. Chem. (1982) 47(26):5225-5226.
Westra, J. et al., “p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis”, Mini-Reviews in Medicinal Chemistry (2006) 6(8):867-874.
Chen, P. et al., “Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors,” Bioorg. Med. Chem. Lett. (2003) 13(7):1345-1348.
Westaway, S.M. et al., “N-tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1,” Bioorg. Med. Chem. Lett. (2006) 16:4533-4536.

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