Isoquinoline composition for the treatment of glaucoma or ocular

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546142, A61K 3147, C07D21724

Patent

active

050617141

ABSTRACT:
The use of isoquinoline derivatives for the treatment of glaucoma or ocular hypertension. The isoquinoline derivatives are of formula I ##STR1## wherein R.sub.1 is a hydrogen or a C.sub.1 -C.sub.6 alkyl group and R.sub.2 is a C.sub.1 -C.sub.6 alkyl group. The stability of the isoquinoline derivatives when used in the form of a solution is improved by incorporating therein compounds having a phenolic hydroxyl group and/or glycols serving as a stabilizer.

REFERENCES:
patent: 4129565 (1978-12-01), Fukushima et al.
patent: 4517365 (1985-05-01), Kayoma et al.
patent: 4659833 (1987-04-01), Takahashi et al.
Fukushima, et al., "Chemical Abstracts", vol. 86, 1977, Col. 86:189739n.

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