Isoquinoline amidoxime derivatives

Details Isoquinoline amidoxime derivatives Isoquinoline amidoxime derivatives

1982-05-25

1984-03-20

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424273B, 424274, 546141, 546157, 546158, 548305, 548477, 548486, 548491, A61K31047, C07D21702

Patent

active

044381212

ABSTRACT:
Heterocyclic amidoxime derivatives of the general formula: ##STR1## wherein R' represents hydrogen or the methyl radical, and R represents the 1-oxo-1H-isoquinolin-2-yl, 2-oxo-2H-quinolin-1-yl, 2,3-dihydro-1H-indol-1-yl, 1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl, 1H-indol-1-yl, 1-oxo-1,3-dihydro-2H-isoindol-2-yl, 2-oxo-3,4-dihydro-2H-quinolin-1-yl, 5-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl, 5-chloro-2-oxo-3-phenyl-2,3-dihydro-1H-benzimidazol-1-yl, 4-chloro-1-oxo-1H-isoquinolin-2-yl or 3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl radical, and - when R' represents the methyl radical - racemates and enantiomers of such compounds, are new compounds useful in therapy, and especially for the treatment of complaints of the central nervous system and for the treatment of depression.

REFERENCES:
patent: 3291799 (1966-12-01), Wenner
patent: 3673188 (1972-06-01), Harsanige et al.
patent: 3686184 (1972-08-01), Bailey
patent: 3927000 (1975-12-01), Bailey
patent: 3931240 (1976-01-01), Binon et al.
patent: 3984470 (1976-10-01), Binon et al.
patent: 4265911 (1981-05-01), Najer et al.

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