Isoquinolinamine and phthalazinamine derivatives: corticotropin-

Details Isoquinolinamine and phthalazinamine derivatives: corticotropin- Isoquinolinamine and phthalazinamine derivatives: corticotropin-

1998-06-22

2000-09-05

Seaman, D. Margaret

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514310, A61K 3147, C07D21722

Patent

active

061145300

ABSTRACT:
Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF.sub.1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety. The compounds have the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein Ar, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and W are various organic and inorganic substituents.

REFERENCES:
patent: 3274185 (1966-09-01), Sigal et al.
patent: 3753988 (1973-08-01), Rodway et al.
patent: 4956371 (1990-09-01), Shoupe
Sindler-Kulyk, M. et al., "Photocycloaddition Reactions of 3-Phenyl-1,2-benzisothiazole and Alkynes", Journal of Org. Chem., vol. 48 No. 8, 1983, pp. 1275-1281.
Holava, H. M. Jr. et al., "1-Substituted 4-Aryl- (or 4-Aralkyl-) phthalazines", New Compounds, vol. 12, 1969, pp. 555-556.

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