Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1990-09-21
1992-08-25
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514533, 562488, 560 81, A61K 3119, A61K 31235, C07C 6366, C07C 6976
Patent
active
051419599
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is CH.dbd.CY--C(CH.sub.3).dbd.CHX wherein X and Y are different and each is of the formula ##STR2## wherein R' and R" independently are H or alkyl of C.sub.1-6 and R.sub.1 includes all possible geometric isomers are demonstrated effective in treating inflammation, both topically and internally. The mechanism appears to be the inhibition of phospholipase A.sub.2 enzymes.
REFERENCES:
patent: 4194007 (1980-03-01), Van Scott et al.
patent: 4456618 (1986-06-01), Dawson et al.
patent: 4568757 (1986-02-01), Carroll et al.
Chemical Abstracts, vol. 93, Oct. 13, 1980, No. 15, Columbus, Ohio, USA, p. 735, Abstract-No. 150 419c.
Chemcial Abstracts, vol. 95, No. 5, Aug. 3, 1981, Columbus, Ohio USA; p. 790; Abstract-No. 43 409u.
Carroll F. Ivy
Lewin Anita
Steiner Stephen A.
Tramposch Kenneth
Bristol--Myers Squibb Company
Clarke Vera C.
Dees Jos,e G.
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