Isoprene derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514655, 514937, 514938, 564367, 564370, A01N 4304, A01N 3302, C07C21100

Patent

active

057564752

ABSTRACT:
Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3,

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patent: 5182267 (1993-01-01), Ogawa et al.
Yamaguchi et al., "Overcoming Drug Resistance in Cancer Cells with Synthetic Isoprenoids", Journal of Nat'l Cancer Institute, vol. 76 (1986), No. 5, pp. 947-953.
Tsuruo et al, "Overcoming of Vincristine Resistance in P388 Leukemia In Vivo and In Vitro Through Enhanced Cytotoxicity of Vincristine and Vinblastine by Verapamil", Cancer Research 41, 1967-1972, May 1981.
Cardarelli et al, Differential Effects of P-Glycoprotein Inhibitors on NIH3T3 Cells Transfected with Wild-type (G185) or Mutant (V185) Multidrug Transporters.

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