Isomorphic copolyoxalates and sutures thereof

Surgery – Truss – Pad

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3 14, 3 15, 128 92B, 128 92C, 128334R, 1283355, 260860, 528307, A61F 124, A61L 1700, C08G 6318, A61F 100

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041410874

ABSTRACT:
Synthetic absorbable sutures are prepared from copolyoxalate polymers having isomorphic sequences. The polymers are derived from mixtures of cyclic and linear diols, each having the same carbon chain length of 6 or 8 atoms. The cyclic diol may be aliphatic or aromatic. The diols are polymerized with dialkyl oxalate, preferably in the presence of an inorganic or organometallic catalyst, to obtain a highly crystalline isomorphic copolyoxalate polymer which is melt extruded and drawn to form oriented filaments. The filaments are characterized by good initial tensile and knot strength and a high order of softness and flexibility. When implanted in living animal tissue, the fibers have good strength retention over a period of at least 21 days and eventually absorb with a minimal degree of adverse tissue reaction.

REFERENCES:
patent: 2071251 (1937-02-01), Carothers
patent: 2111762 (1938-03-01), Ellis
patent: 2952652 (1960-09-01), Beindorff et al.
patent: 3883901 (1975-05-01), Coquard et al.
patent: 4032993 (1977-07-01), Coquard et al.
Korshak, V.V., et al., Acad. Sci. USSR Bull., Division of Chemical Sciences, pp. 889-893 (1957).
Korshak, V.V., et al., "Polyesters", Pergamon Press, N.Y., N.Y., pp. 31-63 (1965).

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