Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-11-20
1993-07-20
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D21106
Patent
active
052295184
ABSTRACT:
The present invention relates to intermediates useful in the process for the preparation of a compound of the formula: ##STR1## wherein R.sub.2a is hydrogen or loweralkyl, R.sub.2b is hydrogen, loweralkyl, cycloalkyl or phenyl and R.sub.1 is loweralkyl, cycloalky, cycloalkylalkyl, phenyl or benzyl. These intermediates are compounds of the formula: ##STR2## wherein R.sub.1, R.sub.2a and R.sub.2b are defined as above.
REFERENCES:
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Bradbury, R. H. et al., Tetrahedron Letters, vol. 30, No. 29, pp. 3845-3848, 1989 "An Efficient Synthesis of the Lactone Corresponding to a Hydroxyethylene Dipeptide Isostere Using Stereoselective Bromolactonisation of a Chiral Acyloxazolidinone".
Chakravarty, P. K., et al., Tetrahedron Letters, vol. 30, No. 4, pp. 415-418, 1989, "The Synthesis of (2S,4S,5S)-5-(N-BOC-Amino-6-Cyclohexyl-4-Hydroxy-2-Isopropyl-Hexanoic Acid Lactone, An Hydroxyethylene Dipeptide Isostere Percurson".
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Baker William R.
Fung Anthony K. L.
Leanna M. Robert
Morton Howard E.
Plata Daniel J.
Abbott Laboratories
Crowley Steven R.
Davis Zinna N.
Ivy C. Warren
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