Isomeric O-phosphonylmethyl derivatives of enantiomeric and race

Details Isomeric O-phosphonylmethyl derivatives of enantiomeric and race Isomeric O-phosphonylmethyl derivatives of enantiomeric and race

1984-01-06

1987-04-21

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

2605024R, 536 27, C07F 938, C07F 965, C07H 1916

Patent

active

046598251

ABSTRACT:
This invention relates to isomeric O-phosphonylmethyl derivatives of the formula I ##STR1## wherein R.sup.5 designates an adenin-9-yl moiety, R.sup.4 are alternately a hydrogen atom and a --CH.sub.2 P(O)(OH).sub.2 group, and the configuration at the carbon atom in the position 2 is S, R or RS.
The compounds according to the invention are biologically active as inhibitors of metabolic processes and in organism they are stable towards enzymes, cleaving phosphomonoester bonds.
The said compounds exhibit also chemosterilizing action on insects.

REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
Antonin Holy and Ivan Rosenberg "Preparation of 5'-O-Phosphonylmethyl Analogues of Nucleoside-5'-Phosphates, 5'-Diphosphates and 5'-Triphosphates" Collection of Czechoslovak Chemical Communications, vol. 47, 1982, pp. 3447-3463.

Affiliated with

Also associated with

Rating

Isomeric O-phosphonylmethyl derivatives of enantiomeric and race does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isomeric O-phosphonylmethyl derivatives of enantiomeric and race, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isomeric O-phosphonylmethyl derivatives of enantiomeric and race will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-753144