Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-02-13
1992-06-30
Rivers, Diana
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514266, 544276, 544277, 544320, 549 22, 549475, 549480, 536 54, A61K 3152, C07D47318, C07D47334
Patent
active
051263475
ABSTRACT:
Isomeric derivatives of 2',3'-dideoxyadenosine and 2',3'-dideoxyguanosine wherein the adenine or guanine base is attached to the 1' position of the iso-dideoxysugar residue by the 9-N position, the novel intermediates used in the synthesis of these compounds, and a method for treating a subject infected with a retrovirus by administering the compounds of the invention.
REFERENCES:
patent: 4772606 (1988-09-01), Sircar et al.
patent: 4788181 (1988-11-01), Driscoll et al.
patent: 4916224 (1990-04-01), Vince et al.
Takano et al., Heterocycles, 16(6):951 (1981).
Hayashi et al., Proc. Natl. Acad. Sci., USA, vol. 85, pp. 6127-6131 (Aug. 1988).
Montgomery et al., J. Org. Chem., vol. 43(4), pp. 541-544 (1978).
Huryn Donna M.
Tam Steve Yik-Kai
Weigele Manfred
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
Leon Bernard S.
Rivers Diana
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