Isomeric 2-chloromethyl-1,4-benzodiazepine or 3-chloro-1,5-benzo

Details Isomeric 2-chloromethyl-1,4-benzodiazepine or 3-chloro-1,5-benzo Isomeric 2-chloromethyl-1,4-benzodiazepine or 3-chloro-1,5-benzo

1985-03-01

1986-06-10

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2602393D, 2602433, 2602444, 2602457, 2603303, 2603309, 514219, 514220, 514250, 514339, 514422, 514453, 514461, 514463, 544343, 544346, 546271, 548518, 549 59, 549433, 549472, C07D31908, C07D48704, C07D49804, A61K 31495

Patent

active

045944369

ABSTRACT:
[1,2]-fused 1,4-benzodiazepine compounds are disclosed corresponding to the general formula I ##STR1## wherein X is an oxygen or sulfur atom or an optionally substituted imino group, R.sub.1 is a hydrogen or halogen atom, lower alkyl radical, a lower alkoxy radical or a nitro group and R.sub.2 is a hydrogen or halogen atom, a lower alkyl radical, a lower alkoxy radical or a nitro group, or if R.sub.1 is a hydrogen atom, R.sub.2 may also be a lower alkylthio radical, or, if R.sub.1 is a hydrogen atom and X is a sulfur atom or an imino group, R.sub.2 may be a trifluoromethyl radical; or R.sub.1 and R.sub.2 are bonded to adjacent carbon atoms and together denote a methylenedioxy or ethylenedioxy radical; R.sub.3 is an optionally substituted furyl, thienyl, pyrrolyl or pyridyl radical and n is zero or, if R.sub.3 is furyl or thienyl, n may be 0 or 1. The compounds may be in the form of their optical isomers or acid addition salts. The compounds exhibit neuroleptic properties. Processes for preparing the compounds and pharmaceutical compositions containing them are also disclosed.

REFERENCES:
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patent: 3846443 (1974-11-01), Moffett
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patent: 4338314 (1982-07-01), Liepmann et al.
patent: 4508716 (1985-04-01), Liepmann et al.
Smith et al., J. Med. Chem. 1980, 23, 952-955.

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