Isolation, purification and sequence determination of cardionatr

Details Isolation, purification and sequence determination of cardionatr Isolation, purification and sequence determination of cardionatr

1987-02-13

1988-08-02

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C07K 710

Patent

active

047614692

ABSTRACT:
Four peptides have been isolated from mammalian atria which exhibit potent diuretic, natiuretic and vasodilatory properties. These peptides derive from a common precursor preprocardionatrin of 152 amino acids in a determined sequence. Cardionatrin III and IV, having molecular weights of about 8,000 and 13,700 respectively have been isolated, purified by chromatographic techniques and their amino acid sequence determined.

REFERENCES:
patent: 4508712 (1985-04-01), Needleman
Vol. 167, No. 2, FEBS 1268, Feb. 1984, pp. 352-357.

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