Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1991-12-09
1993-05-11
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
4352404, 4352523, 435254, 435193, 536 232, C12P 2102, C12N 1554, C12N 910
Patent
active
052100243
ABSTRACT:
A mutation defining a gene for the N.sup..alpha. -acetyltransferase of yeast has been identified and cloned. Mutations in this gene have been constructed and used to produce cells which are substantially incapable of catalyzing N.sup..alpha. -acetylation of protein. Such cells are valuable tools for determining the amino acid sequence of uncharacterized proteins. Such cells are also valuable tools for expressing a recombinant protein lacking an acetyl group at its .alpha.-amino group.
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Lee Fang-Jen S.
Smith John A.
Patterson Jr. Charles L.
The General Hospital Corporation
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