Isolation of stearidonic acid from fatty acid mixtures

Details Isolation of stearidonic acid from fatty acid mixtures Isolation of stearidonic acid from fatty acid mixtures

1990-05-09

1992-07-14

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554191, C11B 700

Patent

active

051304490

ABSTRACT:
Substantially pure stearidonic acid is isolated from a mixture of polyunsaturated fatty acids by fractionating at 25% to 35% by weight solution of fatty acids by high-performance reverse-phase liquid chromatography using a mobile phase of 75% to 95% by weight methanol and 25% to 5% by weight water. The isolated stearidonic acid is used to prepare pharmaceutical compositions which are administered to treat cardiovascular and thrombo-embolic diseases associated with platelet aggregation.

REFERENCES:
patent: 4701468 (1987-10-01), Mendy et al.
patent: 4776984 (1988-10-01), Traitler et al.
Chemical Abstracts, Traitler et al., vol. 109, No. 6, p. 103, 1988, 39686x.
Chemical Abstracts, Wille et al., vol. 107, No. 22, p. 136, 1987, 200830k.
Chemical Abstracts, Wille et al., vol. 110, No. 8, p. 135, 1988, 59848a.
Abstract of JP 050752 (Sep. 18, 1986).
Wille, et al., "Continuous Process for the Concentration of Polyunsaturated Fatty Acids", Fat Sci. Technol., 90(12), 476-481: 1988 (Translation).
Traitler et al., "Fractionation of Blackcurrant Seed Oil", J. Am. Oil Chem. Soc., 65(5) 755-760: 1988.
Wille, et al., "Production of Polyenoic Fish Oil Fatty Acids by Combined Urea Fractionation and Industrial Scale Preparative HPLC", Bev. Fr. Corps. Gras., 34(2) 69-74: 1987.

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