Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Reexamination Certificate
2006-09-12
2006-09-12
Canella, Karen A. (Department: 1643)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
C424S178100, C424S181100, C424S183100, C424S134100, C424S138100, C424S139100, C424S141100, C530S387300, C530S387700, C530S387900, C530S388100, C530S388800, C530S389700, C530S391100, C530S391300, C530S391700
Reexamination Certificate
active
07105149
ABSTRACT:
This invention provides an isolated nucleic acid molecule which encodes immunoglobulin receptor, Immunoglobulin superfamily Receptor Translocation Associated, IRTA, protein. Provided too, are the IRTA proteins encoded by the isolated nucleic acid molecules, IRTA1, IRTA2, IRTA3, IRTA4 or IRTA5 proteins, having the amino acid sequences set forth in any of FIGS.18A,18B-1–18B-3, 18C-1–18C-2, 18D-1–18D-2or18E-1–18E-2. Oligonucleotides of the isolated nucleic acid molecules are provided. Antibodies directed to an epitope of a purified IRTA1, IRTA2, IRTA3, IRTA4 or IRTA5 proteins are also provided, as are pharmaceutical compositions comprising such antibodies or oligonucleotides. Methods for detecting a B cell malignancy in a sample from a subject; diagnosing B cell malignancy in a sample from a subject; detecting human IRTA protein in a sample; and treating a subject having a B cell cancer are also provided.
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Canella Karen A.
Cooper & Dunham LLP
The Trustees of Columbia University in the City of New York
White, Esq. John P.
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