Isolation of coagulation factors I and VIII from biological mate

Details Isolation of coagulation factors I and VIII from biological mate Isolation of coagulation factors I and VIII from biological mate

1975-07-30

1977-05-10

Michl, Paul R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

H23J 106

Patent

active

040227588

ABSTRACT:
The blood coagulation factors I (fibrinogen) and VIII (antihemophilia factor, abbreviated AHF) are isolated in high yields from animal tissue materials such as blood or blood products (e.g. plasma) or plasma fractions by a procedure involving the essential step of adsorption (as in affinity chromatography) of at least one of these factors, in a liquid system, onto a water-insoluble gel matrix primarily composed of a cross-linked sulfated or sulfonated, gel-forming carbohydrate such as cross-linked dextran sulfate-agarose, cross-linked dextran sulfate-dextran, cross-linked heparin-agarose and other such gel matrix-providing substances.

REFERENCES:
patent: 2543808 (1951-03-01), Seegers
patent: 3631018 (1971-12-01), Shanbrom
patent: 3652530 (1972-03-01), Johnson
patent: 3803115 (1974-04-01), Fekete
patent: 3842061 (1974-10-01), Andersson
Chemical Abstracts, vol. 77, No. 71654s, Weiss, 1972.

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