Isolation of an endotoxin inactivator from human plasma, and met

Details Isolation of an endotoxin inactivator from human plasma, and met Isolation of an endotoxin inactivator from human plasma, and met

1987-06-16

1988-10-25

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530351, 530363, 530364, 530380, 530387, 530388, 530412, 530829, A61L 200, A61K 3514, A61K 3702, A61K 39395

Patent

active

047805293

ABSTRACT:
An endotoxin inactivator is isolated from human plasma by anion exchange (DEAE-Sephadex), dye-affinity (Cibracron Blue-Sepharose), and adsorption (on hydroxyapatite) chromatography. The endotoxin inactivator, isolated in essentially pure form, may be used to depyrogenate clinical blood products.

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Skarnes et al., J. Exp. Med., vol. 108, (1958), pp. 685-700.
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Tewlesbury et al., "Purification of Human Angiotensinogen", Supp. II, Circ. Res., vol. 41, No. 41, Oct. 1977, pp. II29-II33.
CA vol. 72, 1970, 88461w Inoue et al.

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