Isolation of an endotoxin inactivator from human plasma

Details Isolation of an endotoxin inactivator from human plasma Isolation of an endotoxin inactivator from human plasma

1985-08-09

1987-06-30

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530380, 530412, 530829, A61L 200, A61K 3514, A61K 3702, A61K 39395

Patent

active

046771948

ABSTRACT:
An endotoxin inactivator is isolated from human plasma by anion exchange (DEAE-Sephadex), dye-affinity (Cibracron Blue-Sepharose), and adsorption (on hydroxyapatite) chromatography. The endotoxin inactivator, isolated in essentially pure form, may be used to depyrogenate clinical blood products.

REFERENCES:
patent: 4382028 (1983-05-01), Paget
Skarnes et al., J. Exp. Med., vol. 108, (1958), pp. 685-700.
Landy et al., J. Exp. Med., vol. 110 (1959), pp. 731-750.
Johnson et al., Amer. Journ. of Path., vol. 88, No. 3, (1977), pp. 559-574.
CA vol. 72, 1970, 88461w, Inoue et al.
Tewksbury et al., "Purification of Human Angiotensinogen", Supp. II, Circ. Res., vol. 41, No. 4, Oct. 1977, pp. II-29-II-33.

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