Isolation of an antineoplastic protein fraction and an antineopl

Details Isolation of an antineoplastic protein fraction and an antineopl Isolation of an antineoplastic protein fraction and an antineopl

1981-06-03

1982-11-16

Lieberman, Allan

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 99, 424177, C07G 700

Patent

active

043594158

ABSTRACT:
The passage of human urine through a bed of adsorbent material results in the adsorption from the urine of antineoplastic substances as determined by in vitro tissue culture techniques utilizing human tumor cells. The adsorbent yields two antineoplastic fractions upon sequential elution. Elution of the low-molecular weight antineoplastic fraction is accomplished by elution with cold aqueous acetone at slightly alkaline pH. Thereafter, elution of the high molecular weight antineoplastic fraction is accomplished by elution with a cold aqueous acetone-glycerol mixture at slightly alkaline pH.
The antineoplastic activities of these fractions are determined by tissue culture techniques employing a variety of human neoplastic cells. Furthermore, the high molecular weight fraction, the antineoplastic urinary protein, also inhibits the progression and causes regression of certain human tumor cells implanted in the nude mouse.

REFERENCES:
patent: 3711377 (1973-11-01), Sloane
Chem Abs. 71:20387a.
Burzynski Physiol. Chem. & Physics pp. 457-468, 6(1974).
Burzynski et al. Physiol. Chem. & Physics pp. 13-22, 8(1976).
Burzynski Physiol. Chem. & Physics pp. 275-279, 8(1976).
Burzynski Physiol. Chem. & Physics pp. 437-447, 5(1973).

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