Isolation of a gene encoding human thyrotropin .beta. subunit

Details Isolation of a gene encoding human thyrotropin .beta. subunit Isolation of a gene encoding human thyrotropin .beta. subunit

1997-10-24

2000-09-05

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435325, 4352523, 435455, 435471, 435476, C12P 2102, C12N 510

Patent

active

061141445

ABSTRACT:
The gene expressing the .beta. subunit of human thyroid stimulating hormone has been isolated. The gene has been incorporated into plasmid pBR322. Vectors can be used to transform cells which in turn produce pure .beta. subunits. The .beta. subunits can then be combined with the alpha subunit of human glycoprotein hormones to produce pure thyroid stimulating hormone.

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Talmadge, K. et al. (1983). The human genome contains seven genes for the .beta.-subunit of chorionic gonadotropin put only one gene for the .beta.-subunit of luteinizing hormone. 2: 281-289 (Exhibit 2).
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