Isolation of a cDNA encoding a protein tyrosine phosphatase whic

Details Isolation of a cDNA encoding a protein tyrosine phosphatase whic Isolation of a cDNA encoding a protein tyrosine phosphatase whic

1993-08-16

1997-01-21

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Vector, per se

435194, 536 232, C12N 1554, C12N 912

Patent

active

055959113

ABSTRACT:
DNA which encodes a protein homologous to the protein tyrosine phosphatases (PTPases) which catalyze the dephosphorylation of proteins in which tyrosyl residues have been phosphorylated through the action of a protein kinase. The protein, which appears as if it will localize to focal adhesions, is also the subject of the present invention. In particular, it relates to cDNA encoding a protein, referred to as PTPH1.

REFERENCES:
Rees, D. J. G. et al., Nature, 347:685-689 (1990).
Tonks, N. K. et al., Biochemistry, 27:8695-8701 (1988).
Streuli, M. et al., The EMBO Journal, 9:2399-2407 (1990).
Cool et al., PNAS vol. 86, pp. 5257-5261, Jul. 1989.
Charbonneau et al. PNAS, vol. 86, pp. 5252-5256, Jul. 1989.
Charbonneau et al., PNAS, vol. 85, pp. 7182-7186, Oct. 1988.
Suggs et al., PNAS, vol. 78, No. 11, pp. 6613-6617, Nov. 1981.
Reeck, et al., Cell, vol. 50, 667 Aug. 28, 1987.

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