Isolation, growth, differentiation and genetic engineering of hu

Details Isolation, growth, differentiation and genetic engineering of hu Isolation, growth, differentiation and genetic engineering of hu

1991-08-22

1996-07-23

Stone, Jacqueline M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435 694, 4352402, 4351723, A61K 4800, C12N 1500

Patent

active

055387225

ABSTRACT:
Myoblasts are produced, conveniently in low or serum-free medium, for use in introduction into a mammalian host, particularly a human host, for treatment of diseases of muscle tissue or acting as carriers for genetic capabilities, particularly correcting a genetic defect or for production of a soluble protein, which may serve in a therapy for the mammalian host. Myoblasts introduced into tissue are able to migrate to sites distal from the site of injection, expanding the area of their effect.

REFERENCES:
Partridge, Muscle & Nerve, vol. 14 pp. 197-212 (Mar. 1991) Partridge, J. Cellular Biochem., Supp. 14E p. 233 (Mar. Apr. 1990).
Law et al, Muscle & Nerve, vol. 11, pp. 525-533 (Jun. 1988).
Melloul et al, EMBO J. vol. 3, No. 5 pp. 983-990 (1984).
Selden et al., Science, vol. 236, pp. 714-718 (8 May 1987).

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