Isolation, characterization, and use of the human and subunit of

Details Isolation, characterization, and use of the human and subunit of Isolation, characterization, and use of the human and subunit of

1994-02-24

1998-09-15

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 691, 435 697, 530324, 530327, 536 234, C07K 14705, C07K 1900, C12N 1562

Patent

active

058079882

ABSTRACT:
The present invention relates to nucleic acid sequences, encoding amino acid sequences of the .beta., and subunit of the human high affinity receptor for immunoglobulin E, and for amino acid sequences of the subunit. A segment of the amino acid sequence containing an antigen recognition activation motif (ARAM) that exhibits different functions than other ARAMS, including that of the ARAM-.gamma. subunit of Fc.epsilon.RI. The invention further relates to a method of producing the receptor by expressing cDNA for its a, .beta., and .gamma. subunits in a host cell simultaneously. Aspects of the invention are methods and compositions to inhibit the function of the human beta subunit, thereby treating or preventing allergic reactions.

REFERENCES:
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