Isolation and use of solid tumor stem cells

Details Isolation and use of solid tumor stem cells Isolation and use of solid tumor stem cells

2006-01-10

2006-01-10

Li, Q. Janice (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of storing cells in a viable state

C435S325000, C435S366000, C435S371000, C435S374000, C435S455000, C424S093100, C424S093200, C424S093210

Reexamination Certificate

active

06984522

ABSTRACT:
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. The solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.

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