Isolation and structure of turbostatins 1-4

Details Isolation and structure of turbostatins 1-4 Isolation and structure of turbostatins 1-4

2006-05-11

2011-11-08

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S017900

Reexamination Certificate

active

08053416

ABSTRACT:
Described herein are novel cerebroside compounds, designated as Turbostatin 1, Turbostatin 2, Turbostatin 3, and Turbostatin 4. These compounds were extracted and isolated from the marine molluskTurbo stenogyrus, and their structures elucidated. The new compounds exhibit significant cancer cell growth inhibition activity against a variety of murine and human cancer cell lines, and as such appear will be useful in the treatment of various forms of neoplastic disease.

REFERENCES:
patent: 5936076 (1999-08-01), Higa et al.
patent: WO 2005/014008 (2005-02-01), None
International Search Report for PCT/US2006/018382 dated Aug. 30, 2006.
Written Opinion of the International Search Authority for PCT/US2006/018382 dated Aug. 30, 2006.

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