Isolation and structure of spongistatin 2, spongistatin 3, spong

Details Isolation and structure of spongistatin 2, spongistatin 3, spong Isolation and structure of spongistatin 2, spongistatin 3, spong

1993-07-02

1994-07-12

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549343, 549344, C01D30777, A01N 4312

Patent

active

053289293

ABSTRACT:
A black Spongia sp. in the Porifera class Demospongiae has been found to contain two new and exceptionally active cell (human cancer) growth inhibitors named spongistatin 2 and spongistatin 3. A bright colored Southwest Indian Ocean sponge Spirastrella spinispirulifera has also been found to contain related human cancer cell growth inhibitors named spongistatin 4 and spongistatin 6. A method of treating human cancer cells with spongistatin 1, spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6 is also disclosed. The approximate mean GI.sub.50 of the disclosed compounds in the NCI cell line panel is about 10.sup.-10 .mu.g/ml.

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