Isolation and structure of spongistatin 1

Details Isolation and structure of spongistatin 1 Isolation and structure of spongistatin 1

1993-01-19

1995-07-25

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D32300

Patent

active

054364000

ABSTRACT:
An Eastern Indian Ocean marine sponge in the genus Spongia was located in the Republic of the Maldives and found to contain a structurally unprecedented macrocyclic lactone named spongistatin 1. The new perhydropyran-containing structure, as shown below, was found to be remarkably potent and specific, log molar TCI.sub.50 to <-10, against twenty human cancer cell lines in the U.S. National Cancer Institute's panel of sixty.

REFERENCES:
patent: 5196447 (1993-03-01), Pettit et al.

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