Isolation and structure of dictyostatin 1

Details Isolation and structure of dictyostatin 1 Isolation and structure of dictyostatin 1

1994-04-19

1995-07-04

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549271, A61K 31335

Patent

active

054300533

ABSTRACT:
A new-type of macrocyclic lactone denominated "dictyostatin 1" bearing a membered ring system is isolated from a Republic of Maldives marine sponge in the genus Spongia sp. and found to strongly inhibit the growth of an important selection of U.S. National Cancer Institute human cancer cell system and the murine P388 lymphocytic leukemia (PS ED.sub.50 3.8.times.10.sup.-4 mg/ml). Dictyostatin 1 has the following structure: ##STR1##

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patent: 4686299 (1987-08-01), Liu et al.
patent: 4996229 (1991-02-01), Moore et al.
patent: 5091411 (1992-02-01), De Kany et al.
patent: 5306716 (1994-04-01), Holt et al.
Boyd, M PPO Updates vol. 3 No. 10 pp. 1-12 1989.

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