Isolation and structural elucidation of the cytostatic linear de

Details Isolation and structural elucidation of the cytostatic linear de Isolation and structural elucidation of the cytostatic linear de

1989-05-18

1991-01-22

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

424550, 514183, 514764, 514765, A01N 6302, A01N 2700, A61K 31015

Patent

active

049869884

ABSTRACT:
The Indian Ocean sea hare Dolabella auricularia has been found to contain a new cell growth inhibitory and antineoplastic (P388 leukemia) cyclodepsipeptide designated dolastatin 13.sup.(1) and a companion substance dehydrodolastatin 13.sup.(2). A series of high field (400 MHz) 2D-NMR experiments including sequential analyses by HMBC and NOE techniques and tandem mass spectrometry provided structural determinations. Dolastatin 13 and dehydrodolastatin 13 represent a new class of cyclodepsipeptides. Pharmaceutical preparations and therapeutic regimens employing these new cytostatic depsipeptides are disclosed. The depsipeptides have the following structure: ##STR1##

REFERENCES:
patent: 4414205 (1983-11-01), Pettit
patent: 4486414 (1984-12-01), Pettit
patent: 4816444 (1989-03-01), Pettit et al.
"Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella auricularia", Pettit et al., J. Am. Chem. Soc., 1989, 111, 5015-5017.

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