Isolation and structural elucidation of the cytostatic cyclodeps

Details Isolation and structural elucidation of the cytostatic cyclodeps Isolation and structural elucidation of the cytostatic cyclodeps

1989-11-13

1992-08-11

Cahn, Christina

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Peptides with at least one nonpeptide bond other than a...

530317, 514908, 930270, 930DIG536, C07K 754, C07K 1102

Patent

active

051380366

ABSTRACT:
A new cytostatic depsipeptide, designated "dolastatin 14", was isolated from the Indian Ocean shell-less mollusk Dolabella auricularia. Dolastatin 14 inhibited growth of the PS leukemia with ED.sub.50 0.0018 .mu.g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 14, its synthetic counterpart and pharmaceutically active derivatives are disclosed. Dolastatin 14 has the structural formula: ##STR1##

REFERENCES:
patent: 4414205 (1983-11-01), Pettit
patent: 4486414 (1984-12-01), Pettit
patent: 4816444 (1989-03-01), Pettit et al.
patent: 4879278 (1989-11-01), Pettit et al.
Rudinger, Peptide Hormones, Parsons (Ed.), U. Park Press, Baltimore, pp. (1976).
Suffness et al., J. Natural Products, vol. 45, pp. 1-14 (1982).

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