Isolation and structural elucidation of the cyclic peptide hymen

Details Isolation and structural elucidation of the cyclic peptide hymen Isolation and structural elucidation of the cyclic peptide hymen

1989-11-30

1992-07-14

Chan, Y. Christina

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

930270, 930DIG546, C07K 764

Patent

active

051304147

ABSTRACT:
A new and demonstratably active cyclo-octapeptide is isolated from the South Pacific Ocean Hymeniacidon sp. and structurally elucidated. The substance, herein denominated Hymenistatin 1, demonstrated utility by inhibiting tumor growth when measured by the National Cancer Institute P388 leukemia cell line (ED.sub.50 =3.5 .mu.g/mL). Hymenistatin 1 has the following structure: ##STR1##

REFERENCES:
patent: 4977138 (1990-12-01), Okuhara et al.
Pinedo, Med. Oncol. and Tumor Pharmacother. vol. 3, No. 2, pp. 63-69 (198 ).
Suffness et al., J. Natural Products, vol. 45, pp. 1-14, 1982.

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