Isolation and structural elucidation of cephalostatins 1-4

Details Isolation and structural elucidation of cephalostatins 1-4 Isolation and structural elucidation of cephalostatins 1-4

1988-03-14

1989-10-10

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544230, C07D49122, A61K 31495

Patent

active

048732451

ABSTRACT:
The marine worm Cephalodiscus gilchristi (Hemichordata phylum) from Southeast Africa has been found to contain powerful inhibitors of the murine P388 lymphocytic leukemia, herein denominated "cephalostatin 1, cephalostatin 2, cephalostatin 3 and cephalostatin 4". Pharmaceutical preparations containing the substances and methods of use are described. Cephalostatin 1-3 having the following structure: ##STR1## whereas cephalostatin 4 is an oxy- derivative of cephalostatin 2, having oxygen interposed in the 14-15 double bond as shown below: ##STR2##

REFERENCES:
Pettit, Chem Abs 108, 128802d (1988).

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