Isolation and purification of the eighth gene of HTLV-III

Details Isolation and purification of the eighth gene of HTLV-III Isolation and purification of the eighth gene of HTLV-III

1986-10-20

1990-10-16

Teskin, Robin L.

Chemistry: molecular biology and microbiology

Vector, per se

536 27, 4351723, 435235, C12N 1500, C07H 1512

Patent

active

049634976

ABSTRACT:
The present invention is the isolation and purification of a newly discovered gene of the AIDS virus, HTLV-III, which encodes a protein which is immunogenic and recognized by sera of some HTLV-III seropositive people. Furthermore, the gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3' end which distinguishes molecular clones of the HTLV-III cell line from viral genomes of related viruses (i.e., other HTLV-III isolates, LAV, ARV, etc.).

REFERENCES:
Ratner et al., Nature, 313:277-284, 1985.

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