Isolation and production of a cyclophilin-like protein endogenou

Details Isolation and production of a cyclophilin-like protein endogenou Isolation and production of a cyclophilin-like protein endogenou

1998-08-14

2000-10-03

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435325, 4352523, 43525411, 4353201, 536 237, C12P 2106, C12N 120, C12N 100, C07H 2104

Patent

active

061271489

ABSTRACT:
The present invention relates to the use of nematode "cyclophilin-like proteins (CLP)", in a method for identifying compounds capable of binding to and/or inhibiting the peptidyl-prolylcistransisomerase activity of these proteins. Such compounds may be further screened for their ability to inhibit nematode parasites which are not susceptible to the anti-parasitic effects of CsA.

REFERENCES:
patent: 5079143 (1992-01-01), Klein
patent: 5482850 (1996-01-01), Carlow
Fischer, et al., Nature, 337:476-478 (1989).
Takahashi, et al., Nature, 337:473-475 (1989).
Bachinger, J. Biol. Chem., 262:17144-17148 (1987).
Steinmann, et al., J. Biol. Chem., 266:1299-1303 (1991).
Liu, et al., Biochemistry, 30:2306-2310 (1991).
Schreiber et al, Immunol. Today, 13:136-142 (1992).
Behforouz, et al., J. Immunol. 136:3067-3075 (1986).
Nickell, et al., Infect & Immunol., 37:1093-1100 (1982).
Thommen-Scott, Agents & Actions, 11:770-773 (1981).
Nilsson, et al., Parasitol. Immunol., 7:19-27 (1985).
Pons, et al., Exper. Parasitol. 67:190-198 (1988).
Munro et al., Parasitol., 100:19-29 (1990a).
Munro et al., Parasitol., 100:29-34 (1990b).
Hashiguchi et al., J. Helminthol., 62:251-256 (1988).
Wastling, et al., Parasitol., 104:531-538 (1992).
Bout, et al., Trans. Roy. Soc. Trop. Med. Hyg., 78:670-671 (1984).
Zahner et al., J. Helminthol., 61:282-290 (1987).
Bolas-Fernandez, et al., Parasit. Immunol., 10:111-116 (1988).
Koletsky, J. Immunol., 137:1054-1059 (1986).
Argaet et al., J. Parasitol., 78:660-664 (1992).
Lightowlers, et al., Mol. Biochem. Parasitol., 36:287-290 (1989).
Chappell et al., Parasitol., 105:S25-S40 (1992).
Lawrence, et al., Parasit. Immunol., 14:371 (1992).
Andersen, et al., Proc. Natl. Acad. Sci. USA, 90:542-546 (1993).
Kieffer, et al., J. Biol. Chem., 268:12303-12310 (1993).
Bartling, et al., Plant Mol. Biol., 19:529-530 (1992).
Haendler, et al., EMBO J., 6:947-950 (1987).
Hasel et al. Nucleic Acids Res., 18:4019 (1990).
Gasser, et al., Proc. Natl. Acad. Sci., 87:9519-9523 (1990).
Stammes, et al., Cell, 65:219-227 (1991).
Haendler, et al., Gene, 83:39-46 (1989).
McCombie, et al., Nature Genet., 1:124-131 (1992).
Ke, et al., Proc. Natl. Acad. Sci. USA, 88:9483-9487 (1993).
Lee, Science, 239:1288-1291 (1988).
Page et al., Biochemistry 34:11545-11550 (1995).

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