Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Blood
Patent
1988-11-10
1993-03-09
Rosen, Sam
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Blood
435 2, 4351721, 4351723, 4352402, 43524026, A61K 3550, A61K 3514
Patent
active
051925532
ABSTRACT:
The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing. In particular, the present invention relates to the therapeutic use of fetal or neonatal stem cells for hematopoietic (or immune) reconstitution. Hematopoietic reconstitution with the cells of the invention can be valuable in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. In another embodiment, fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence can be used for hematopoietic reconstitution in gene therapy. In a preferred embodiment of he invention, neonatal or fetal blood cells that have been cryopreserved and thawed can be used for utologous (self) reconstitution.
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Boyse Edward A.
Broxmeyer Hal E.
Douglas Gordon W.
Biocyte Corporation
Rosen Sam
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