Isolation and elucidation of Cephalostatins 5 and 6

Details Isolation and elucidation of Cephalostatins 5 and 6 Isolation and elucidation of Cephalostatins 5 and 6

1989-07-28

1991-09-10

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D49122, A61K 31495

Patent

active

050475320

ABSTRACT:
The Indian Ocean (South African) marine worm Cephalodiscus gilchristi (Hemichordata Phylum) has been found to contain a series of unusual disteroidal alkaloids designated the Cephalostatins which demonstrate exceptionally potent lymphocytic leukemia (murine P388) cell line inhibitory activity (to ED.sub.50 10.sup.-9 .mu.g/ml). Two new disteriodal alkaloids bearing aromatic C-rings having ED.sub.50 of 10.sup.-2 and 10.sup.-3 .mu.g/mL were isolated and assigned structures based on rigorous interpretation of two-dimensional 400 MHz.sup.1 H and .sup.13 C-nmr. These substances were denominated Cephalostatin 5 and Cephalostatin 6, respectively.

REFERENCES:
patent: 4873245 (1989-10-01), Pettit et al.
Pettit et al., Chemical Abstracts, vol. 111, No. 229304, (1989), (Abstract or Can. J. Chem., (1989)).
Kamano et al., Chemical Abstracts, vol. 111, No. 4545, (1989), (Abstract for Tenne Yuki Kagobutsu Toronkai Koen Yoshishu, (1988)).

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