Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of detaching cells – digesting tissue or establishing...
Patent
1995-10-10
2000-01-25
Smith, Lynette F.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of detaching cells, digesting tissue or establishing...
435325, 435379, 435384, 435389, 435394, 435395, 435399, 435400, 435401, 435402, 435174, 435 29, 435 11, C12N 500, C12N 506, C12N 1100, C12N 1104
Patent
active
060177608
ABSTRACT:
A perfusion device such as a liver assist device containing a housing defining a perfusion inlet and a perfusion outlet, a porous membrane structure mounted within said housing to define a perfusion compartment and an adjacent hepatocyte compartment, and porcine hepatocytes isolated from a porcine liver by retrograde perfusion.
REFERENCES:
patent: 4352887 (1982-10-01), Reid et al.
patent: 4994388 (1991-02-01), Hillegas et al.
patent: 4996154 (1991-02-01), Gabriels, Jr.
patent: 5043260 (1991-08-01), Jauregui
patent: 5122470 (1992-06-01), Banes
patent: 5153133 (1992-10-01), Schwarz et al.
patent: 5162225 (1992-11-01), Sager et al.
patent: 5175092 (1992-12-01), Gabriels, Jr.
patent: 5264359 (1993-11-01), Enami et al.
patent: 5270192 (1993-12-01), Li et al.
Waxman et al. 1990 Biochemical Journal 271 113-119, Jan. 1990.
Quistorff 1985 Biochem J 229 221-6, Jan. 1, 1985.
Alpini et al., Recent Advances in the Isolation of Liver Cells, Hepatology 20:494-514, 1994.
Arterburn et al., A Morphological Study of Differentiated Hepatocytes In Vitro, Hepatology 22:175-187, 1995.
Basile et al., The Pathogenesis and Treatment of Hepatic Encephalopathy: Evidence for the Involvement of Benzodiazepine Receptor Ligands, Pharmacol. Rev. 43:27-71, 1991.
Basile et al., Brain Concentrations of Benzodiazepines are Elevated in an Animal Model of Hepatic Encephalopath, Proc. Natl. Acad. Sci. USA 87:5263-5267, 1990.
Bryson, Acetaminophen, Ch. 35 in Comprehensive Review in Toxicology, 2nd ed, Aspen Publishers, 1989, pp. 415-422.
Butterworth et al., Ammonia: Key Factor in the Pathogenesis of Hepatic Encephalopathy, Neurochemical Pathology 6:1-12, 1987.
Clayton et al., Liver-Specific RNA Metabolism in Hepatoma Cells: Variations in Transcription Rates and MRNA Levels, Molecular and Cellular Biology 5:2633-2641, 1985.
Colin and Sirois, Simultaneous Determination of the Major Metabolites of Styrene and Acetaminophen, and of Unchanged Acetaminophen . . . Chromatography, Journal of Chromatography 377:243-251, 1986.
Demetriou et al., New Method of Hepatocyte Transplantation and Extracorporeal Liver Support, Ann Surg. 204:259-271, 1986.
Dicker et al., Increased Catalytic Activity of Cytochrome P-450IIE1 in Pericentral Hepatocytes Compared to Periportal Hepatocytes . . . Rats, Biochimica et Biophysica Acta 1073:316-323, 1991.
Dixit et al., Hepatocyte Immobilization on Phema Microcarriers and Its Biologically Modified Forms, Cell Transplantation 1:391-399, 1992.
Enat et al., Hepatocyte Proliferation In Vitro: Its Dependence on the Use of Serum-Free Hormonally Defined Medium and Substrata of Extracellular Matrix, PNAS USA 81:1411-1415, 1984.
Fujioka et al., Carboxyfluorescein (CFSE) Labelling of Hepatocytes for Short-Term Localization Following Intraportal Transplantation, Cell Transplantation 3:397-408, 1994.
Gebhardt, Metabolic Zonation of the Liver: Regulation and Implications for Liver Function, Pharmac. Ther. 53:275-354, 1992.
Gebhardt et al., Different Drug Metabolizing Capapcities in Cultued Periportal and Pericentral Hepatocytes, Biochemical Pharmacology 48:761-766, 1994.
Gerlach et al., Nonenzymatic Versus Enzymatic Hepatocyte Isolation From Pig Livers for Larger Scale. . . Liver Cell Perfusion Systems, The International Journal of Artificial Organs 16:677-681, 1993.
Gerlach et al., Comparison of Four Methods for Mass Hepatocyte Isolation from Pig and Human Livers Transplantation 57:1318-1322, 1994.
Gerlach et al., Hepatocyte Culture Between Woven Capillary Networks: A Microscopy Study, Artificial Organs 18:226-230, 1994.
Gupta et al., Hepatocyte Transplantation: An Alternative System for Evaluating Cell Survival and Immunoisolation, The International Journal of Artificial Organs 16:155-163, 1993.
Hager et al., Neonatal Hepatocyte Culture on Artificial Capillaries, Assaio Journal 6:26-35, 1983.
Hayner et al., Ponceau S.: A Sensitive Method for Protein Determination in Freshly Isolated and Cultured Cells Journal of Tissue Culture Methods 7:77-80, 1982.
Ho et al., Determination of Nitrazepam and Temazepam in Plasma by High-Performance Liquid Chromatography, Therapeutic Drug Monitoring 5:303-307, 1983.
Isom et al., Maintenance of Differentiated Rat Hepatocytes in Primary Culture, PNAS USA 82:3252-3256, 1985.
Jauregui and Sharda, Diazepam Metabolic Activity in Long Term Monolayer Cultures of Rat, Rabbit, and Piglet Hepatocytes, Abstract, Artificial Organs 15:295, 1991.
Jauregui et al., Xenobiotic Induction of P-450 PB-4 (IIB1) and P-450C (IA1) and Associated Monooxygenase Activities in Primary Cultures of Adult Rat Hepatocytes, Xenobiotica 21:1091-1106, 1991.
Jauregui et al., Trypan Blue Dye Uptake and Lactate Dehydrogenase in Adult Rat Hepatocytes--Freshly Isolated Cells . . . Monolayer Cultures, In Vitro 17:1100-1110, 1981.
Jauregui et al., Diazepam Metabolism in Perfused Cultures of Adult Rat Hepatocytes, In Hepatic Encephalopathy Butterworth & Layrargues (eds.), Humana Press, Clifton NJ, 1989, pp. 339-351.
Jauregui et al., P-450 Activity in Monolayer Cultures of Hepatocytes Seeded in Polystyrene Tissue Culture Dishes, Trans. Am. Soc. Artif. Intern. Organs, vol. XXXII, 357-359, 1986.
Jauregui et al., Trypan Blue Dye Uptake and Lactate Dehydrogenase in Adult Rat Hepatocytes--Freshly Isolated Cells, Cell Suspensioins, and Primary Monolayer Cultures, In Vitro 17:1100-1110, 1981.
Jauregui et al., In Vivo Evaluation of a Hollow Fiber Liver Assist Device, Hapatology 21:460-469, 1995.
Jauregui et al., Adult Rat Hepatocyte Cultures as the Cellular Component of an Artificial Hybrid Liver, In Biomaterials in Artificial Organs, Paul et al. (eds.), Macmillan Press, 1983, pp. 130-140.
Jauregui et al., Attachment and Long Term Survival of Adult Rat Hepatocytes in Primary Monolayer Cultures: Comparison of . . . Media Formulations, In Vitro Cellular & Developmental Biology 22:13-22 1986.
Jenkins et al., The Role of Transplantation in Liver Disease, Surgical Clinics of North America 69:371-382 1989.
Jones et al., Fulminant Hepatic Failure, Ch. 17 in Manifestations of Abnormal Liver Function, pp. 460-492.
Kasai et al., Cellulose Microcarrier for High-Density Culture of Hepatocytes, Transpslantation Proceedings 24:2933-2934, 1992.
Kay, Hepatocyte Transplantation for Liver Gene Therapy, Cell Transplantation 2:405-406, 1993.
Kelly et al., Modulation of the Liver Specific Phenotype in the Human Hepatoblastoma Line HEP G2, In Vitro Cellular & Developmental Biology 25:217-222, 1989.
Kobayashi et al., Enhanced Adhesion and Survival Efficiency of Liver Cells in Culture Dishes Coated with a Lactose-Carrying Styrene Homopolymer, Makromol. Chem., Rapid Commun. 7:645-650, 1986.
Koide et al., Formation of Multicellular Spheroids Composed of Adult Rat Hepatocytes in Dishes with Positively Charged Surfaces . . . Nonadherent Environments, Experimental Cell Research 187:227-235, 1990.
Macklis et al., Cross-Linked Collagen Surface for Cell Culture That is Stable, Uniform, and Optically Superior to Conventional Surfaces, In Vitro Cellular & Developmental Biology 21:189-194, 1985.
Michalopoulos et al., Control of Hepatocyte Replication by Two Serum Factors, Cancer Research 44:4414-4419, 1984.
Mito and Kusano, Hepatocyte Transplantation in Man, Cell Transplantation 2:65-74, 1993.
Morsiani et al., Automated Large-Scale Production of Porcine Hepatocytes for Bioartificial Liver Support, Transplantation Proceedings 26:3505-3506, 1994.
Muller and Jauregui, Letters to the Editor, Artificial Organs 18:44-45, 1993.
Munoz et al., Liver Transpslantation, Medical Clinics of North America 73:1011-1039, 1989.
Naik et al., Cell Transplantation, Influence of Different Substrates in Detoxification Activity of Adult Rat Hepatocityes in Long-Term Culture: Implications for Transplantation, 1:61-69, 1992.
Peleman et al., Orthotopic Liver Transplantation for Acute and Subacute Hepatic Failure in Adults, Hepatology 7:484-489, 1987.
Ponder et al., Mouse Hepatocytes Migrate to Liver Parenchyma and Function Indefinitely After Intrasplenic Transplantation, Proc. Natl. Acad. Sci. USA 88:1217-1221, 1991.
Reid et al., Culturing Hepatocytes and Other Differentiated Cells, Hepato
Jauregui Hugo O.
Naik Sharda
Santangini Henry
Trenkler Donna M.
Rhode Island Hospital
Smith Lynette F.
Zeman Mary K
LandOfFree
Isolation and culture of porcine hepatocytes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isolation and culture of porcine hepatocytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolation and culture of porcine hepatocytes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2315228