Isolation and culture of adrenal medullary endothelial cells pro

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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435 68, 435948, 530383, C12N 500, C12P 2100, C12R 191, A61K 3514

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active

046703942

ABSTRACT:
The present invention discloses a new line of endothelial cell of adrenal medullary origin capable of producing blood clotting Factor VIII:C. A method of isolating and culturing said cell line has also been disclosed. Factor VIII:C is useful in treating hemophilia.

REFERENCES:
patent: 4348315 (1982-09-01), Blomback
patent: 4370264 (1983-01-01), Kotitschke et al.
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4446134 (1984-05-01), Naito et al.
patent: 4534972 (1985-08-01), Lembach
patent: 4540573 (1985-09-01), Neurath et al.
Differential Monoamine Metabolism in Isolated Bovine Adrenal Medullary Endothelial Cells, Dipak K. Banerjee, Moussa B. H. Youdim and Harvey B. Pollard, J. Pharm. Pharmacol 36 (Suppl) 1984, 15 W Meeting Date, Aug. 4-6, 1984.
Synthesis of Factor VIII Antigen by Cultured Human Endothelial Cells, Eric A. Jaffe, Annals New York Academy of Sciences, 240:62-69, 1975.
An Osmotic Mechanism for Exocytosis from Dissociated Chromaffin Cells, Harvey B. Pollard, Christopher J. Pazoles, Carl E. Creutz, Janet H. Scott, Oren Zinder and Adair Hotchkiss, Journal of Biological Chemistry, vol. 259, No. 2, Jan. 25/84, pp. 1114-1121.
Hoyer, L. W. et al, "Localization in Endothelial Cells by Immunofluorescent Microscopy", 1973, J. of Clin. Invest., vol. 52, 2737-2744.
Jaffe, E. A. et al., "Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells", J. Clin. Invest., vol. 52, pp. 2757-2764, 1973.
Crickard, K., "Isolation and Identification of Human Fetal Adrenal Medullary Cells in Vitro", 1982, J. Clin. Endocrin. Metab., vol. 55, pp. 1143-1148.
Eiden, L., "Synthesis and Release of Vasoactive Polypeptide", 1982, 66th Annual Mtg. of FASEB, Apr. 15-23, 1982, Fed. Proc. 41(4), 1982.
Banerjee, D. et al, "Cultured Endothelial Cells from Bovine Adrenal Medulla", J. Cell Biology, 1984, 99(4 Part 2), Mtg. Date, Nov. 12-16, 1984.
Warhol, M., "The Ultrastructural Localization of von Willebrand Factor", 1984, American J. Pathology, vol. 117, pp. 310-315.
Jaffe, E. A., R. L. Nachman, C. G. Becker and C. R. Minick, J. Clin. Invest. 52: 2745-2756.
Jaffe, E. A., Ann. New York Acad. Sci., 401 (Endothelium): 163-170, 1982.
Jaffe, E. A., Biology of Endothelial Cells, Boston: Martinus Nijhoff Publishers, 1984, pp. 1-13, 59-65, 86-96, 108-117.

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