Isolation and cloning of the human ARSA-I gene and uses thereof

Details Isolation and cloning of the human ARSA-I gene and uses thereof Isolation and cloning of the human ARSA-I gene and uses thereof

1996-07-01

1999-07-27

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352523, 43525233, 4353201, 435348, 435325, 536 232, C12N 914, C12N 120, C12N 1500, C07H 2104

Patent

active

059289260

ABSTRACT:
The present invention provides DNA encoding a human ARSA-I protein selected from the group consisting of: (a) isolated DNA which encodes a human ARSA-I protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a human ARSA-I protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a human ARSA-I protein. Also provided are pharmaceutical compositions comprising human human ARSA-I protein and a pharmaceutically acceptable carrier and host cells transfected with the vector of the present invention said vector expressing a human ARSA-I protein.

REFERENCES:
Hillier et al. EST-STS database, Jun. 23, 1995, accesssion H08524.
Silver et al. (1988) Ann. Rev. Microbiol. 42, 717-743.

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