Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-05
1998-12-01
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 231, 536 243, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
058436529
ABSTRACT:
The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.
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patent: 4801531 (1989-01-01), Frossard
patent: 5068175 (1991-11-01), Prashad
patent: 5223425 (1993-06-01), Flier et al.
patent: 5288607 (1994-02-01), Emorine
Kwon et al., "Molecular structure and chromsomal mapping of the human homolog of the agouti gene" PNAS 91: 9760-9764, 1994.
Green et al. Clinical Chemistry 37: 1263-1267, 1991.
Jones W. Gary
Lockheed Martin Energy Systems, Inc.
Pennington Edward A.
Rees Dianne
Stafford Shelley L.
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