Isolation and characterization of a novel chaperone protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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435195, C07K 900

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active

056462492

ABSTRACT:
This invention relates to the identification and molecular characterization of the human and rat STCH chaperone protein including the corresponding gene sequence, gene fragments and protein fragments. The invention also relates antibodies to STCH and to assays to detect the presence of STCH genes, transcripts and protein in a sample.

REFERENCES:
patent: 5188964 (1993-02-01), McGuire et al.
patent: 5348945 (1994-09-01), Berberian et al.
Bork, et al. "An ATPase Domain Common to Prokaryotic Cell Cycle Proteins, Sugar Kinases, Actin, and hsp70 Heat Shock Proteins" Proc. Natl. Acad. Sci. 89: 7290-7294 (1992).
Bole, et al. "Posttranslational Association of Immunoglobulin Heavy Chain Binding Protein with Nascent Heavy Chains in Nonsecreting and Secreting Hybridomas" J. Cell Biology 102: 1558-1566 (1986).
Chappell, et al. "The ATPase Core of a Clathrin Uncoating Protein" J. of Biological Chem. 262(2): 746-751 (1987).
Chirico, et al. "70K Heat Shock Related Proteins Stimulate Protein Translocation into Microsomes" Nature 332: 805-810 (1988).
Deshaies, et al. "A Subfamily of Stress Proteins Facilitates Translocation of Secretory and Mitochondrial Precursor Polypeptides" Nature 332: 800-805 (1988).
Flynn, et al. "Peptide-Binding Specificity of the Molecular Chaperone BiP" Nature 353: 726-730 (1991).
Flynn, et al. "Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly" Science 245: 385-390 (1989).
Gething, et al. "Protein Folding in the Cell" Nature 355: 33-44 (1992).
Hendrick, et al. "Molecular Chaperone Function of Heat-Shock Proteins" Annu. Rev. Biochem. 62: 349-384 (1993).
Hightower, Lawrence. "Heat Shock, Stress Proteins, Chaperones, and Proteotoxicity" Cell 66: 191-197 (1991).
Hunt, et al. "Conserved Features of Eukaryotic hsp70 Genes Revealed by Comparison with the Nucleotide Sequence of Human hsp70" Proc. Natl. Acad. Sci. 82:6455-6459 (1985).
Kassenbrock, et al. "Interaction of Heavy Chain Binding Protein (BiP/GRP78) with Adenine Nucleotides" EMBO Journal 8(5): 1461-1467 (1989).
Li, et al. "Tumor Rejection Antigen gp96/grp94 is an ATPase: Implications For Protein Folding and Antigen Presentation" EMBO Journal 12(8): 3143-3151 (1993).
Munro, et al. "An Hsp70-like Protein in the ER: Identity with the 78 kd Glucose-Regulated Protein and Immunoglobulin Heavy Chain Binding Protein" Cell 46: 291-300 (1986).
Munro, et al. "A C-Terminal Signal Prevents Secretion of Luminal ER Proteins" Cell 48: 899-907 (1987).
Otterson, et al. "Alternative Splicing of the RBP1 Gene Clusters in an Internal Exon that Encodes Potential Phosphorylation Sites" Oncogene 8: 949-957 (1993).
Pelham "Speculations on the Functions of the Major Heat Shock and Glucose-Regulated Proteins" Cell 46: 959-961 (1986).
Ritossa, et al. "A New Puffing Pattern Induced by Temperature Shock and DNP in Drosophila" Experentia 18: 571-573 (1962).
Rothman, James. "Polypeptide Chain Binding Proteins: Catalysts of Protein Folding and Related Processes in Cells" Cell 59: 591-601 (1989).
Sadis, et al. "Unfolded Proteins Stimulate Molecular Chaperone Hsc70 ATPase by Accelerating ADP/ATP Exchange" Biochemistry 31: 9406-9412 (1992).
Sanger, et al. "DNA Sequencing with Chain-Terminating Inhibitors" Proc. Natl. Acad. Sci. 74(12): 5463-5467 (1977).
Smith, et al. "Single-step Purification of Polypeptide Expressed in E. coli as Fusions with Glutathione S-transferase" Gene 67: 31-40 (1988).
Sturzbecher, et al. "Mutant p53 Proteins Bind hsp 72/73 Cellular Heat Shock-Related Proteins in SV40-transformed Monkey Cells" Oncogene 1: 201-211 (1987).
Ting, et al. "Human Gene Encoding the 78,000-Dalton Glucose-Regulated Protein and Its Pseudogene: Structure, Conservation, and Regulation" DNA 7(4): 275-286 (1988).
Tissieres, et al. "Protein Synthesis in Salivary Glands of Drosophila melanogaster: Relation to Chromosome Puffs" J. Mo.. Biol. 84: 389-398 (1974).
Welch, et al. "Biochemical Characterization of the Mammalian Stress Proteins and Identification of Two Stress Proteins as Glucose- and Ca.sup.2+ -Ionophore-Regulated Proteins" J. Biol. Chem. 258(11): 7102-7111 (1983).
Yehiely, et al. "The Gene for the Rat Heat-Shock Cognate, hsc70, Can Suppress Oncogene-mediated Transformation" Cell Growth & Differentiation 3: 803-809 (1992).
Adams, M.D., et al. (1993) "3400 expressed sequence tags identify diversity of transcripts from human brain" Nature Genetics, 4:256-267.
Wu, B., et al. (1985) "Structure and expression of the human gene encoding major heat shock protein HSP70" Molec. Cell. Biol., 5(2):330-341.

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