Isolation and characterisation of genes resistant to anthracycli

Details Isolation and characterisation of genes resistant to anthracycli Isolation and characterisation of genes resistant to anthracycli

1993-08-09

1997-09-09

Jagannathan, Vasu S.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 43525235, 435 9141, 435 78, 536 237, C12N 500, C12N 1500, C07H 1700

Patent

active

056655649

ABSTRACT:
Doxorubicin resistance can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 1 or 2 of the accompanying drawings or a restriction fragment derived therefrom containing a gene coding for doxorubicin resistance.

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Abstracts of the Annual Meeting of the American Society for Microbiology, 88th Annual Meeting, 8-13 May 1988, Miami Beach, FL., American Soc. For Microbiology (US) K.J. Stutzman-Engwall et al.: "Cloning and identification of genes involved in daunorubicin production in Streptomyces peucetius", see page 261, abstract 0-2.
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Mol. Gen. Genet., vol. 205, 1986, Springer-Verlag, T. Murakami et al.: "The bialaphos biosynthesis genes of Streptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster", pp. 42-50.
Chemical Abstracts, vol. 104, 1986, (columbus, Ohio, US), J.S. Lampel et al.: "Transformation and transfection of anthracycline-producing streptomycetes", p. 178, resume 103498p & Appl. environ, Microbiol. 1986, 51(1), 126-31.
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The Journal of Antibiotics, vol. 59, No. 1, Jan. 1986, R. Crameri et al.: "Increased production of aminoglycosides associated with amplified antibiotic resistance genes", p. 128.

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