Isolating aminoarginine and use to block nitric oxide formation

Details Isolating aminoarginine and use to block nitric oxide formation Isolating aminoarginine and use to block nitric oxide formation

1989-09-13

1991-10-22

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

435106, 43524031, 514565, C07C24100

Patent

active

050597124

ABSTRACT:
Pharmaceutically pure physiologically active N.sup.G -aminoarginine (i.e., the L or D,L form) or pharmaceutically acceptable salt thereof is administered in a nitric oxide synthesis inhibiting amount to a subject in need of such inhibition (e.g. a subject with low blood pressure or needing immunosuppressive effect) or is added to a medium containing isolated organs, intact cells, cell homogenates or tissue homogenates in an amount sufficient to inhibit nitric oxide formation to elucide or control the biosynthesis, metabolism or physiological role of nitric oxide.
N.sup.G -amino-L-arginine is prepared and isolated as a pharmaceutically pure compound by reducing N.sup.G -nitro-L-arginine, converting L-arginine by-product to L-ornithine with arginase and separating N.sup.G -amino-L-arginine from the L-ornithine. N.sup.G -amino-D,L-arginine is prepared in similar fashion starting with N.sup.G -nitro-D,L-arginine.

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