Isolated viral protein TNF antagonists

Details Isolated viral protein TNF antagonists Isolated viral protein TNF antagonists

1994-08-18

1995-11-07

Walsh, Stephen G.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530351, 530395, C07K 14065

Patent

active

054649382

ABSTRACT:
Isolated viral proteins, and pharmaceutical compositions made therefrom, are disclosed which are capable of binding to cytokines, thereby functioning as cytokine antagonists. Also disclosed are processes for preparing isolated vital protein cytokine antagonists.

REFERENCES:
Bozan, Immunology Today 11(10), 1990, pp. 350-354.
Daspin et al, Science, 257, 1992, pp. 369-373.
Casman, Cytokine 5(2) 1993, pp. 95-106.
Mallett et al EMBO J 1990, pp. 1063-1068.
Patel et al, J. Gen Virol 71, 1990, pp. 2013-2021.
Pickup et al, PNAS, 79, 1982 pp. 7112-7116.
Parsons et al, Virology, 175, 1990, pp. 69-80.
Hu, Virology 181, 1991, pp. 716-720.
Gooding et al, J. Immunol 145(9) 1990, pp. 3080-3086 (abstract only).
Levi et al, PNAS 90(4) 1993, pp. 1541-1545 (abst only).

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