Isolated, tyrosinase derived peptides and uses thereof

Details Isolated, tyrosinase derived peptides and uses thereof Isolated, tyrosinase derived peptides and uses thereof

1994-04-26

1996-05-21

Budens, Robert D.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C07K 706, C07K 700

Patent

active

055191177

ABSTRACT:
The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.

REFERENCES:
patent: 4898814 (1990-02-01), Kwon
Roitl et al., Immunology, 3rd Ed., Moshy-YearBook, St. Louis, MO., 1993 pp. 6.10-6.11.
Wolfel et al., "Two Tyrosinase Nonapeptides Recognized On HLA-A2 Melanomas by Autologous Cytolytic T Lymphocytes," Eur. J. Immunol. 24: 759-764, Mar. 1994.
Brichard, et al., "The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas", J. Exp. Med. 178: 489-495 (1993).
Coulie, et al, "Genes Coding For Tumor Antigens Recognized by Human Cytolytic T Lymphocytes", J. Immunotherapy 14: 104-109 (1993).
Slingluff, et al, "Recognition of Human Melanoma Cells by HLA-A2.1 Restricted Cytotoxic T Lymphocytes As Mediated By At Least Six Shared Peptide Epitopes", J. Immunol. 150 (7): 2955-2963 (Apr. 1, 1993).
Barinaga, "Getting Some `Backbone`: How MHC Binds Peptides" Science 257: 880-881 (Aug. 14, 1992).
Falk, et al, "Allele Specific Motifs revealed by sequencing of self-peptides eluted from MHC molecules", Nature 351: 290-296 (May 23, 1991).
Wolfel, et al, "Lysis of Human Melanoma Cells by Autologous Cytolytic T Cells Clones", J. Exp. Med. 170: 797-810 (Sep. 1989).

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