Isolated, tyrosinase derived peptides and uses thereof

Details Isolated, tyrosinase derived peptides and uses thereof Isolated, tyrosinase derived peptides and uses thereof

1996-01-17

1998-04-28

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4241931, 530328, G01N 3353, A61K 39385, A61K 3804

Patent

active

057443165

ABSTRACT:
The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.

REFERENCES:
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patent: 5487391 (1996-01-01), Boon-Falleur
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Greenberg, Therapy of murine leukemia with cyclophosphamide and immune lyt-2+ cells: cytolytic T cells can mediate eradication of disseminated leukemia, J. Immunology, Vo. 136, No. 5, p. 1917, col. 2, 1st sentence of the 1st paragraph, Mar. 1986.
Ruppert et al., Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing, The EMBO J. vol. 7, No. 9, pp. 2715-2722, p. 2715, col. 1, lines 5-7, Jun. 1988.
Traversari, et al., Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes, Immunogenetics 35: 145-152, Abstract, first sentence, p. 146, col. 2, "CTL clones", p. 147, column 1, Sc, 1992.
Brichard, et al, "The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas", J. Exp. Med. 178: 489-495 (1993).
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Slingluff, et al, "Recognition of Human Melanoma Cells by HLA-A2.1 Restricted Cytotoxic T Lymphocytes As Medicated By At Least Six Shared Peptide Epitopes", J. Immunol. 150(7): 2955-2963 (Apr. 1, 1993).
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