Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Patent
1996-06-21
2000-05-16
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
530328, 530300, 530868, 4241851, 435 724, 4353723, C07K 706, A61K 3808, C12N 506
Patent
active
060639008
ABSTRACT:
The invention describes peptides derived from tumor rejection antigen precursor MAGE-2. These peptides bind with HLA-A2 molecules, thus presenting complexes which provoke cytolytic T cell production. The resulting "CTLs" are specific for complexes of HLA-A2 and the peptide. The complexes can be used to generate monoclonal antibodies. The cytolytic T cells produced may be used in the context of immunotherapy, such as adoptive transfer.
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Boon-Falleur Thierry
Kast W. Martin
Melief Cornelis J. M.
van der Bruggen Pierre
Visseren Marjan J. W.
Chan Christina Y.
Lubet Martha
Ludwig Institute for Cancer Research
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